EDK
Editome Disease Knowledgebase
Hirschsprung’s disease
| Disease name | Hirschsprung’s disease |
|---|---|
| Classfication | Gastrointestinal system disease |
| Related Enzyme(s) | |
| EFO | - |
| DOID | - |
| OMIM | |
| NCI | |
| Definition | A megacolon that is characterized by a blockage of the large intestine due to improper muscle movement in the bowel. |
| Gene symbol | Disease | Enzyme | Editing Sites | Editing Type | miRBase | PMID | Description |
|---|---|---|---|---|---|---|---|
| hsa-miR-142-3p | ADAR2 | 1 | U-to-C | NA | MiR-142-3p accelerated migration and prolif- eration of cells via down-regulation of the STAU1. In summary, we established a pivotal LPS-ADAR2-miR-142-3p-STAU1 axis to provide a link between LPS and HSCR. |